GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements

Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells. In available structures, Lys-295 in the lariat loop of arrestin-3 and its homologue Lys-294 in arrestin-2 directly interact with t...

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Bibliographic Details

Published in:	Cells
Main Authors:	Chen Zheng, Liana D. Weinstein, Kevin K. Nguyen, Abhijeet Grewal, Eugenia V. Gurevich, Vsevolod V. Gurevich
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	arrestin GPCR JNK3 conformation signaling bias
Online Access:	https://www.mdpi.com/2073-4409/12/12/1563