Dynamic alterations in PD-1/PD-L1 expression level and immune cell profiles based on radiation response status in mouse tumor model

IntroductionBased on the immunologic effects of anti-cancer treatment and their therapeutic implications, we evaluated radiotherapy (RT)-induced dynamic alterations in programmed death-1 (PD-1)/PD ligand-1 (PD-L1) expression profiles.MethodsLocal RT with 2 Gy × 5 or 7.5 Gy × 1 was administered to th...

Full description

Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yi Na Yoon, Min Ho Choe, Moonkyoo Kong, Weon Kuu Chung, Jae-Sung Kim, Yu Jin Lim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	radiotherapy PD-1/PD-L1 dynamic alterations dose fractionation tumor immune microenvironment flow cytometry
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.989190/full