Dysfunction of the noradrenergic system drives inflammation, α-synucleinopathy, and neuronal loss in mouse colon

Clinical and pathological evidence revealed that α-synuclein (α-syn) pathology seen in PD patients starts in the gut and spreads via anatomically connected structures from the gut to the brain. Our previous study demonstrated that depletion of central norepinephrine (NE) disrupted brain immune homeo...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Sheng Song, Dezhen Tu, Chengbo Meng, Jie Liu, Belinda Wilson, Qingshan Wang, Yen-Yu Ian Shih, Hui-Ming Gao, Jau-Shyong Hong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	α-synuclein noradrenergic system gut-brain axis inflammation Parkinson’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1083513/full