Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types

Abstract Targeting mitochondrial oxidative phosphorylation (OXPHOS) to treat cancer has been hampered due to serious side-effects potentially arising from the inability to discriminate between non-cancerous and cancerous mitochondria. Herein, comprehensive mitochondrial phenotyping was leveraged to...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Ilya N. Boykov, McLane M. Montgomery, James T. Hagen, Raphael T. Aruleba, Kelsey L. McLaughlin, Hannah S. Coalson, Margaret A. Nelson, Andrea S. Pereyra, Jessica M. Ellis, Tonya N. Zeczycki, Nasreen A. Vohra, Su-Fern Tan, Myles C. Cabot, Kelsey H. Fisher-Wellman
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-10-01
Online Access:	https://doi.org/10.1038/s41598-023-43963-5