The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations

Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are used to predict risk of complex diseases, such as obesity. Current PRSs only include common variants (minor allele frequency (MAF) ≥1%), whereas the contribution of rare variants in PRSs to predict disea...

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出版年:	Frontiers in Endocrinology
主要な著者:	Zhe Wang, Shing Wan Choi, Nathalie Chami, Eric Boerwinkle, Myriam Fornage, Susan Redline, Joshua C. Bis, Jennifer A. Brody, Bruce M. Psaty, Wonji Kim, Merry-Lynn N. McDonald, Elizabeth A. Regan, Edwin K. Silverman, Ching-Ti Liu, Ramachandran S. Vasan, Rita R. Kalyani, Rasika A. Mathias, Lisa R. Yanek, Donna K. Arnett, Anne E. Justice, Kari E. North, Robert Kaplan, Susan R. Heckbert, Mariza de Andrade, Xiuqing Guo, Leslie A. Lange, Stephen S. Rich, Jerome I. Rotter, Patrick T. Ellinor, Steven A. Lubitz, John Blangero, M. Benjamin Shoemaker, Dawood Darbar, Mark T. Gladwin, Christine M. Albert, Daniel I. Chasman, Rebecca D. Jackson, Charles Kooperberg, Alexander P. Reiner, Paul F. O’Reilly, Ruth J. F. Loos
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2022-05-01
主題:	polygenic risk score rare variants obesity risk burden score PRS-CS lassosum
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fendo.2022.863893/full