The Membrane-Active Phytopeptide Cycloviolacin O2 Simultaneously Targets HIV-1-infected Cells and Infectious Viral Particles to Potentiate the Efficacy of Antiretroviral Drugs

<b>Background:</b> Novel strategies to increase the efficacy of antiretroviral (ARV) drugs will be of crucial importance. We hypothesize that membranes of HIV-1-infected cells and enveloped HIV-1 particles may be preferentially targeted by the phytopeptide, cycloviolacin O2 (CyO2) to sig...

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Bibliographic Details

Published in:	Medicines
Main Authors:	Samantha L. Gerlach, Partha K. Chandra, Upal Roy, Sunithi Gunasekera, Ulf Göransson, William C. Wimley, Stephen E. Braun, Debasis Mondal
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Subjects:	cyclotides cycloviolacin O2 CyO2 HIV-1 protease inhibitors fusion inhibitors antiretroviral drugs
Online Access:	https://www.mdpi.com/2305-6320/6/1/33