Maximizing the potential of aggressive mouse tumor models in preclinical drug testing

Abstract Atypical teratoid rhabdoid tumor (ATRT) is an aggressive embryonal brain tumor among infants and young children. Two challenges exist for preclinical testing in ATRT. First, genetically quiet, ATRT is a difficult tumor to target molecularly. Tumor cells need to divide to propagate tumor gro...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	M. Tarek Elghetany, Jia-Min Ho, Lois Hew Shi-Qi, Sekar Karthik, Jack M. F. Su, Qi Lin, YuChen Du, Jianhe Shen, Wing-Yuk Chow, Ching C. Lau, Adekunle Adesina, Angela Major, Anat Erdreich-Epstein, Kam-Man Hui, Xiao-Nan Li, Wan-Yee Teo
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-06-01
Online Access:	https://doi.org/10.1038/s41598-021-91167-6