Ageing-Induced Decline in Primary Myeloid Cell Phagocytosis Is Unaffected by Optineurin Insufficiency

Optineurin is a ubiquitin-binding adaptor protein involved in multiple cellular processes, including innate inflammatory signalling. Mutations in optineurin were found in amyotrophic lateral sclerosis, an adult-onset fatal neurodegenerative disease that targets motor neurons. Neurodegeneration resul...

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Bibliographic Details

Published in:	Biology
Main Authors:	Josip Peradinovic, Nikolina Mohovic, Katarina Bulic, Andrea Markovinovic, Raffaello Cimbro, Ivana Munitic
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	phagocytosis ageing optineurin neurodegeneration inflammation
Online Access:	https://www.mdpi.com/2079-7737/12/2/240