Chemical synthesis of peptidoglycan mimetic–disaccharide-tetrapeptide conjugate and its hydrolysis by bacteriophage T5, RB43 and RB49 L-alanyl-D-glutamate peptidases

Background Endolysins of a number of bacteriophages, including coliphages T5, RB43, and RB49, target the peptidoglycans of the bacterial cell wall. The backbone of these bacterial peptidoglycans consist of alternating N-acetylglucosamine and N-acetylmuramic acid residues that is further “reinforced”...

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Bibliographic Details

Published in:	PeerJ
Main Authors:	Viatcheslav Azev, Alexey Chulin, Maxim Molchanov, Dmitry Prokhorov, Galina Mikoulinskaia, Vladimir N. Uversky, Viktor Kutyshenko
Format:	Article
Language:	English
Published:	PeerJ Inc. 2021-05-01
Subjects:	Peptidoglycan mimetic Bacteriophage Disaccharide-tetrapeptide conjugate Chemical synthesis NMR spectroscopy Substrate hydrolysis
Online Access:	https://peerj.com/articles/11480.pdf