Efficient Ocular Delivery of VCP siRNA via Reverse Magnetofection in RHO P23H Rodent Retina Explants

The use of synthetic RNA for research purposes as well as RNA-based therapy and vaccination has gained increasing importance. Given the anatomical seclusion of the eye, small interfering RNA (siRNA)-induced gene silencing bears great potential for targeted reduction of pathological gene expression t...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Merve Sen, Marco Bassetto, Florent Poulhes, Olivier Zelphati, Marius Ueffing, Blanca Arango-Gonzalez
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Subjects:	siRNA delivery magnetic nanoparticles magnetofection RNAi therapy ocular therapy retinal organotypic culture
Online Access:	https://www.mdpi.com/1999-4923/13/2/225