Mechanically interlocked molecular architectures of valinomycin as cancer targeted prodrugs

Abstract Macrocyclic drugs are promising agents for treating a variety of diseases. However, these compounds usually present delivery limitations, such as low tissue selectivity and poor cellular uptake, which may impair efficacy and clinical translation. Here, we propose a molecular machine approac...

Full description

Bibliographic Details

Published in:	Nano Select
Main Authors:	Yoshihiro Tachihara, Yasuhiro Nakagawa, Takuya Miyazaki, Yasutaka Anraku, Horacio Cabral
Format:	Article
Language:	English
Published:	Wiley-VCH 2022-08-01
Subjects:	macrocyclic drugs molecular machines pancreatic cancer rotaxane valinomycin
Online Access:	https://doi.org/10.1002/nano.202100368