Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatments of parasitic diseases targeting the trypansosmat...

詳細記述

書誌詳細

出版年:	Pharmaceuticals
主要な著者:	Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis, Maria Paola Costi
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2021-11-01
主題:	GSK Kinetobox PTR1 DHFR-TS Leishmaniasis trypanosomiasis drug discovery
オンライン･アクセス:	https://www.mdpi.com/1424-8247/14/12/1246