Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis – study protocol for a randomised controlled trial

Introduction The chronic inflammatory state in rheumatoid arthritis (RA) augments the risk of cardiovascular disease (CVD), with pro-inflammatory cytokines tumour necrosis factor (TNF) and interleukin 6 (IL-6) playing a vital role. Consequently, biological disease-modifying antirheumatic drugs (bDMA...

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Bibliographic Details

Published in:	BMJ Open
Main Authors:	Søren Jacobsen, Lars Køber, Lene Dreyer, Bente Klarlund Pedersen, Niels Vejlstrup, Pil Højgaard, Iben Elmerdahl Rasmussen, Simon Jønck, Regitse Højgaard Christensen, Peter Godsk Jørgensen, Morten Asp Vonsild Lund, Ronan M G Berg, Malte Lund Adamsen, Helga Ellingsgaard
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-05-01
Online Access:	https://bmjopen.bmj.com/content/13/5/e068600.full