Topiramate Reprofiling for the Attenuation of Cadmium-Induced Testicular Impairment in Rats: Role of NLRP3 Inflammasome and AMPK/mTOR-Linked Autophagy

Topiramate, a promising drug classically used for the management of neurological disorders including epilepsy and migraine, has demonstrated marked anti-inflammatory and anti-apoptotic actions in murine models of cardiac post-infarction inflammation, wound healing, and gastric/intestinal injury. How...

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Bibliographic Details
Published in:Pharmaceuticals
Main Authors: Hany H. Arab, Hayat A. Abd El Aal, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, El-Shaimaa A. Arafa, Ahmed M. Ashour, Ahmed M. Kabel, Ahmed H. Eid
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Subjects:
topiramate
cadmium
testicular damage
NLRP3 inflammasome
apoptosis: autophagy
Online Access:https://www.mdpi.com/1424-8247/15/11/1402

Internet

https://www.mdpi.com/1424-8247/15/11/1402

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