Achieving scalable expansion of therapeutic porcine hepatocytes in vivo through serial transplantation

Abstract The clinical application of hepatocyte transplantation has been significantly hindered by the scarcity of primary hepatocytes and the functional immaturity of in vitro–produced hepatocytes. By performing serial allogeneic hepatocyte transplantation in CRISPR/Cas9‐mediated Fah‐knockout pigs,...

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Bibliographic Details

Published in:	Animal Models and Experimental Medicine
Main Authors:	Zhiqiang Han, Xin Wang, Dawei Yu, Jing Wang, Ke Sun, Siqi Wang, Ying Zhang, Guihai Feng, Wei Li, Tang Hai, Jilong Ren
Format:	Article
Language:	English
Published:	Wiley 2025-07-01
Subjects:	cellular therapy hepatocyte large‐scale expansion regeneration single‐cell RNA sequencing
Online Access:	https://doi.org/10.1002/ame2.70052