NGF and proNGF regulate functionally distinct mRNAs in PC12 cells: an early gene expression profiling.

The biological activities of NGF and of its precursor proNGF are quite distinct, due to different receptor binding profiles, but little is known about how proNGF regulates gene expression. Whether proNGF is a purely pro-apoptotic molecule and/or simply a "less potent NGF" is still a matter...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Mara D'Onofrio, Francesca Paoletti, Ivan Arisi, Rossella Brandi, Francesca Malerba, Luisa Fasulo, Antonino Cattaneo
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	http://europepmc.org/articles/PMC3109000?pdf=render