Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway

Diabetic neuropathic pain (DNP) is a common complication of diabetes mellitus (DM) and is characterized by spontaneous pain and neuroinflammation. The Sigma-1 receptor (Sig-1R) has been proposed as a target for analgesic development. It is an important receptor with anti-inflammatory properties and...

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Bibliographic Details

Published in:	Brain Research Bulletin
Main Authors:	Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Subjects:	Sigma-1 receptor Dorsal root ganglia Neuroinflammation Microglia-like cell PRE-084 GSK-3β
Online Access:	http://www.sciencedirect.com/science/article/pii/S0361923025000383