Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities

IntroductionAntibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection against the virus. While virus neutralization is a key function of spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play a role in protection or pathogenesi...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Jéromine Klingler, Shreyas Kowdle, Juan C. Bandres, Rozita Emami-Gorizi, Raymond A. Alvarez, Priyanka G. Rao, Fatima Amanat, Charles Gleason, Giulio Kleiner, Viviana Simon, Alexis Edelstein, Claudia Perandones, Chitra Upadhyay, Benhur Lee, Catarina E. Hioe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	COVID-19 vaccines adaptive immunity immunoglobulins antibodies Fc functions
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1382619/full