Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy

This review focuses on the immunosuppressive effects of tumor angiogenesis and coagulation on the tumor microenvironment (TME). We summarize previous research efforts leveraging these observations and targeting these processes to enhance immunotherapy outcomes. Clinical trials have documented improv...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Areez Shafqat, Mohamed H. Omer, Eman Nayaz Ahmed, Ali Mushtaq, Eman Ijaz, Zara Ahmed, Khaled Alkattan, Ahmed Yaqinuddin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	immunotherapy tumor microenvironment angiogenesis thrombosis vascular normalization hypoxia
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1200941/full