Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome

Abstract Background Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically exploitable vulnerabilities remain largely elusive in HPV-negative head a...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Felix Broghammer, Irina Korovina, Mahesh Gouda, Martina Celotti, Johan van Es, Inga Lange, Cornelia Brunner, Jovan Mircetic, Robert P. Coppes, Olivier Gires, Andreas Dahl, Michael Seifert, Nils Cordes
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	HNSCC Fibroblast growth factor receptor Epithelial-to-mesenchymal transition Epidermal growth factor receptor Radiosensitization Radioprotection
Online Access:	https://doi.org/10.1186/s12943-024-01954-8