Dicentrine and its N-oxide derivatives induces apoptotic and necrotic cell death in prostate cancer cell lines

As part of our continuous research for the discovery of anticancer natural products, the effects of alkaloid (6aS)-dicentrine (1) and its respective (6aS,6S)- (1a) and (6aS,6R)-(1b) N-oxides against two prostate cancer cell lines (PC3 and DU145) were evaluated for the first time. Alkaloid 1 exhibite...

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Bibliographic Details

Published in:	European Journal of Medicinal Chemistry Reports
Main Authors:	Ranyelison S. Machado, Daniela C. Tristão, Natália M. Araújo, Elias Jorge Muniz Seif, Kayo Alexandre S. da Cruz, Mirian G. Morale, Ileana Gabriela S. de Rubio, João Henrique G. Lago, Rodrigo E. Tamura
Format:	Article
Language:	English
Published:	Elsevier 2025-04-01
Subjects:	Dicentrine N-oxide derivatives PCa cell lines Apoptosis Necrosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772417425000135