The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy

Abstract Background Standard neuropathologic analysis of Alzheimer’s brain relies on traditional fluorescence microscopy, which suffers from limited spatial resolution due to light diffraction. As a result, it fails to reveal intricate details of amyloid plaques. While electron microscopy (EM) offer...

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Bibliographic Details

Published in:	Cell & Bioscience
Main Authors:	Björn Johansson, Sho Oasa, Aida Muntsant Soria, Ann Tiiman, Linda Söderberg, Ebba Amandius, Christer Möller, Lars Lannfelt, Lars Terenius, Lydia Giménez-Llort, Vladana Vukojević
Format:	Article
Language:	English
Published:	BMC 2023-08-01
Subjects:	Alzheimer’s disease Amyloid beta peptide Amyloid fibrils Immunohistochemistry Super-resolution STED microscopy Next generation drug design
Online Access:	https://doi.org/10.1186/s13578-023-01086-4