White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes

Abstract Background The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer’s disease. During middle age, cognitively healthy APOE-ε4 carriers already show several brain alterations that resemble those of Alzheimer's disease (AD), but to a s...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Grégory Operto, Raffaele Cacciaglia, Oriol Grau-Rivera, Carles Falcon, Anna Brugulat-Serrat, Pablo Ródenas, Rubén Ramos, Sebastián Morán, Manel Esteller, Nuria Bargalló, José Luis Molinuevo, Juan Domingo Gispert, for the ALFA Study
Format:	Article
Language:	English
Published:	BMC 2018-05-01
Subjects:	Diffusion tensor imaging Apolipoprotein E White matter integrity Aging Cognitively normal subjects
Online Access:	http://link.springer.com/article/10.1186/s13195-018-0375-x