Targeted NMDA Receptor Interventions for Autism: Developmentally Determined Expression of GluN2B and GluN2A-Containing Receptors and Balanced Allosteric Modulatory Approaches

Various ASD risk alleles have been associated with impairment of NMDA receptor activation (i.e., NMDA Receptor Hypofunction) and/or disturbance of the careful balance between activation mediated by GluN2B-subtype and GluN2A-subtype-containing NMDA receptors. Importantly, although these various risk...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Stephen I. Deutsch, Zachary N. M. Luyo, Jessica A. Burket
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Subjects:	NMDA receptor autism spectrum disorder positive allosteric modulators negative allosteric modulators
Online Access:	https://www.mdpi.com/2218-273X/12/2/181