Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells

Abstract The cyclin D1-Cyclin-Dependent Kinases 4 and 6 (CDK4/6) complex is crucial for the development of melanoma. We previously demonstrated that targeting CDK4/6 using small molecule inhibitors (CDK4/6i) suppresses BrafV600E melanoma growth in vitro and in vivo through induction of cellular sene...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Justin Kim, Bryce Brunetti, Ayanesh Kumar, Ankit Mangla, Kord Honda, Akihiro Yoshida
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-12-01
Online Access:	https://doi.org/10.1038/s41419-024-07284-3