Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids.

Multicellular tumour spheroid (MCTS) cultures are excellent model systems for simulating the development and microenvironmental conditions of in vivo tumour growth. Many documented cell lines can generate differentiated MCTS when cultured in suspension or in a non-adhesive environment. While physiol...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Samuel L Collins, Rodolphe Hervé, C W Keevil, Jeremy P Blaydes, Jeremy S Webb
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028123&type=printable