Affective phenotypes in heterozygous LRRK2 R1441G knock-in mice

Several missense mutations in the LRRK2 gene are linked to familial Parkinson’s disease (PD). Although LRRK2 mutant mouse models typically lack gross motor impairments, their contribution to non-motor PD symptoms remains largely underexplored. In this study, we showed that the R1441G missense mutati...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Marcus H. F. Ng, Jimmy W. Y. Lam, Zoe Y. K. Choi, Hui-Fang Liu, Philip W. L. Ho, Benson W. M. Lau, Benjamin K. Yee
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	animal model Parkinson’s disease leucine-rich repeat kinase 2 behavioural phenotyping depression
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1629897/full