Affective phenotypes in heterozygous LRRK2 R1441G knock-in mice

Several missense mutations in the LRRK2 gene are linked to familial Parkinson’s disease (PD). Although LRRK2 mutant mouse models typically lack gross motor impairments, their contribution to non-motor PD symptoms remains largely underexplored. In this study, we showed that the R1441G missense mutati...

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