Recent Advances in Translational Pharmacokinetics and Pharmacodynamics Prediction of Therapeutic Antibodies Using Modeling and Simulation

Therapeutic monoclonal antibodies (mAbs) have been a promising therapeutic approach for several diseases and a wide variety of mAbs are being evaluated in clinical trials. To accelerate clinical development and improve the probability of success, pharmacokinetics and pharmacodynamics (PKPD) in human...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Kenta Haraya, Haruka Tsutsui, Yasunori Komori, Tatsuhiko Tachibana
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Subjects:	therapeutic monoclonal antibodies pharmacokinetics pharmacodynamics modeling and simulation human prediction TMDD
Online Access:	https://www.mdpi.com/1424-8247/15/5/508