Ictal phase-amplitude coupling as a biomarker for seizure onset zone in neocortical epilepsy

ObjectiveTo assess ictal phase–amplitude coupling (PAC) dynamics during seizure generation and explore whether ictal PAC analysis can help identify the seizure onset zone (SOZ) in neocortical epilepsy.MethodsWe analyzed ictal intracranial electroencephalography recordings from 22 seizures in six pat...

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Bibliographic Details

Published in:	Frontiers in Neurology
Main Authors:	Kazuki Nishioka, Yasushi Iimura, Takumi Mitsuhashi, Hiroharu Suzuki, Tetsuya Ueda, Kazuki Nomura, Yao Miao, Toshihisa Tanaka, Hiroshi Otsubo, Hidenori Sugano, Akihide Kondo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	high-frequency oscillations modulation index phase-amplitude coupling neocortical epilepsy ictal EEG analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1632484/full