Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models

Abstract Adolescent idiopathic scoliosis (AIS) is the most prevalent pediatric spine disorder, developing in the absence of obvious physiological defects. Genome sequencing and functional studies have demonstrated association of musculoskeletal collagen variants and cartilaginous extracellular matri...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Patrick G. Pumputis, Ran Xu, Josh Gopaul, Arash Panahifar, Vida Erfani, Jenica L. M. Van Gennip, B. Frank Eames, Nikan Fakhari, Jerome Baranger, David E. Lebel, Olivier Villemain, Brian Ciruna
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Online Access:	https://doi.org/10.1038/s41467-025-63742-2