Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

Summary: Neurogenesis in specific brain regions in adult mammals decreases with age. Progressive reduction in the proliferation of neural stem and progenitor cells (NS/PCs) is a primary cause of this age-associated decline. However, the mechanism responsible for this reduction is poorly understood....

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Bibliographic Details
Published in:Stem Cell Reports
Main Authors: Yoshitaka Kase, Kinya Otsu, Takuya Shimazaki, Hideyuki Okano
Format: Article
Language:English
Published: Elsevier 2019-06-01
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119301328