Chlojaponilactone B Attenuates THP-1 Macrophage Pyroptosis by Inhibiting the TLR/MyD88/NF-κB Pathway

Pyroptosis, an innate immune response, plays a crucial role in the pathological process of inflammatory diseases. Although pyroptosis blockade is considered a potential therapeutic strategy, no ideal candidate drug has been identified. The natural product Chojaponilactone B (CJB) has demonstrated an...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Qiyin Wen, Bingjinfeng Zhan, Lu Jin, Zijing Peng, Ju Liu, Longping Zhu, Depo Yang, Xinjun Xu, Lixia Zhang, Ge Li, Zhimin Zhao
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	Chojaponilactone B lindenane sesquiterpenoid lactone NLRP3 inflammasome pyroptosis anti-inflammation <i>Chloranthus</i>
Online Access:	https://www.mdpi.com/1424-8247/17/3/402