Molecular basis of autoimmune disease protection by MDA5 variants

Summary: MDA5 recognizes double-stranded RNA (dsRNA) from viruses and retroelements. Cooperative filament formation and ATP-dependent proofreading confer MDA5 with the necessary sensitivity and specificity for dsRNA. Many MDA5 genetic variants are associated with protection from autoimmune disease w...

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Bibliographic Details
Published in:Cell Reports
Main Authors: Rahul Singh, Joe D. Joiner, Alba Herrero del Valle, Marleen Zwaagstra, Ida Jobe, Brian J. Ferguson, Frank J.M. van Kuppeveld, Yorgo Modis
Format: Article
Language:English
Published: Elsevier 2025-06-01
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500525X

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http://www.sciencedirect.com/science/article/pii/S221112472500525X

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