Near-Infrared Photoimmunotherapy Combined with CTLA4 Checkpoint Blockade in Syngeneic Mouse Cancer Models

Near infrared photoimmunotherapy (NIR-PIT) is a newly developed and highly selective cancer treatment that induces necrotic/immunogenic cell death. It employs a monoclonal antibody (mAb) conjugated to a photo-absorber dye, IRDye700DX, which is activated by NIR light. Tumor-targeting NIR-PIT is also...

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Bibliographic Details

Published in:	Vaccines
Main Authors:	Yasuhiro Maruoka, Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Daiki Fujimura, Hiroaki Wakiyama, Takuya Kato, Tadanobu Nagaya, Peter L. Choyke, Hisataka Kobayashi
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Subjects:	near infrared photoimmunotherapy immune checkpoint blockade CTLA4 CD44 monoclonal antibodies
Online Access:	https://www.mdpi.com/2076-393X/8/3/528