Cardiac-targeted delivery of nuclear receptor RORα via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy

Abstract Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials. Ultrasound-targeted microbubble destruction (UTMD) has be...

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Bibliographic Details

Published in:	Biomaterials Research
Main Authors:	Shanjie Wang, Kegong Chen, Ye Wang, Zeng Wang, Zhaoying Li, JunChen Guo, Jianfeng Chen, Wenhua Liu, Xiaohui Guo, Guangcan Yan, Chenchen Liang, Huai Yu, Shaohong Fang, Bo Yu
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science (AAAS) 2023-05-01
Subjects:	Melatonin RORα Ultrasound-targeted microbubble destruction, UTMD Sepsis-induced cardiomyopathy Oxidative stress Mitochondria
Online Access:	https://doi.org/10.1186/s40824-023-00377-8