Self-assembled extracellular matrix-lipid nanoparticle composite for site-specific siRNA delivery to improve cardiac repair post-myocardial infarction

Cardiovascular disease remains a leading cause of mortality, highlighting the critical need for novel therapeutic strategies. RNA-based therapeutics, including siRNA and mRNA, offer promising approaches for cardiac diseases, yet their clinical application is limited by low heart specificity and subo...

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出版年:	Materials Today Bio
主要な著者:	Xinming Wang, Yiming Zhong, Bei Qian, Shixing Huang, Qiang Long, Haonan Zhang, Qiang Zhao, Xiaofeng Ye
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2025-10-01
主題:	Localized delivery siRNA therapy Extracellular matrix-lipid nanoparticle composite Myocardial infarction Epidermal growth factor receptor
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2590006425007756