Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality in HFpEF. The TMAO precursor trimethylamine (TMA)...

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Bibliographic Details
Published in:Cardiovascular Diabetology
Main Authors: Salmina J. Guivala, Konrad A. Bode, Jürgen G. Okun, Ece Kartal, Edzard Schwedhelm, Luca V. Pohl, Sarah Werner, Sandra Erbs, Holger Thiele, Petra Büttner
Format: Article
Language:English
Published: BMC 2024-08-01
Subjects:
HFpEF
TMAO
Intestinal microbiome
Inflammation
Intestinal barrier
FMO3
Online Access:https://doi.org/10.1186/s12933-024-02398-6

Internet

https://doi.org/10.1186/s12933-024-02398-6

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