Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6

Abstract Foam cell formation is a hallmark of the early phase of atherosclerosis. Growing evidence has demonstrated that vascular smooth muscle cells (VSMCs) comprise a considerable proportion of foam cells. Liver kinase B1 (LKB1) plays a crucial part in cardiovascular diseases. However, the role of...

Full description

Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Qiming Deng, Hongxuan Li, Xiaolin Yue, Chenghu Guo, Yuanyuan Sun, Chang Ma, Jiangang Gao, Yue Wu, Bin Du, Jianmin Yang, Cheng Zhang, Wencheng Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-08-01
Online Access:	https://doi.org/10.1038/s41419-023-06054-x