STUDY OF THE THERMAL STABILITY OF BARNASE PROTEIN MUTANTS WITH MOLKERN SOFTWARE

A thermal stability study of several barnase mutants has been carried out by the λ dynamics method. The method has been implemented in the MOLKERN software package. Mutations of amino acids with non-zero charge are chosen for the study, because in this case λ dynamics gives results differing dramati...

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Bibliographic Details

Published in:	Вавиловский журнал генетики и селекции
Main Authors:	E. S. Fomin, N. A. Alemasov
Format:	Article
Language:	English
Published:	Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2014-12-01
Subjects:	barnase molecular dynamics λ dynamics free energy difference protein thermal stability
Online Access:	https://vavilov.elpub.ru/jour/article/view/57