Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B.
ATP7B is a human copper-transporting P1B-type ATPase that is involved in copper homeostasis and resistance to platinum drugs in cancer cells. ATP7B consists of a copper-transporting core and a regulatory N-terminal tail that contains six metal-binding domains (MBD1-6) connected by linker regions. Th...
| Published in: | PLoS Computational Biology |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-09-01
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| Online Access: | https://doi.org/10.1371/journal.pcbi.1010074 |