Polymorphism Pro64His within galectin-3 has functional consequences at proteome level in thyroid cells

IntroductionThe single nucleotide polymorphism (SNP) rs4644 at codon 64 of galectin-3 (gal-3, gene name: LGALS3), specifying the variant proline (P64) to histidine (H64), is known to affect the protein’s functions and has been associated with the risk of several types of cancer, including differenti...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Roberto Silvestri, Lorenzo Zallocco, Alda Corrado, Maurizio Ronci, Romina Aceto, Benedetta Ricci, Monica Cipollini, Irene Dell’Anno, Chiara De Simone, Giuseppina De Marco, Eleonora Ferrarini, Daniela Beghelli, Maria Rosa Mazzoni, Antonio Lucacchini, Federica Gemignani, Laura Giusti, Stefano Landi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	galectin-3 (gal3) functional polymorphism rs4644 differentiated thyroid carcinoma (DTC) CRISPR/Cas9 proteome papillary thyroid carcinoma (PTC)
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2024.1380495/full