The Effect of cAMP-PKA Activation on TGF-β1-Induced Profibrotic Signaling

Background: The cAMP-PKA signaling pathway and TGF-β1-dependent fibrosis pathways are of particular importance in ADPKD progression, but the cross-talk between these pathways remains unclear. Therefore, we used an MDCK-cell model and embryonic kidney-cyst model to study the regulatory role of cAMP-P...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Lin Weng, Weiling Wang, Xiaohong Su, Yong Huang, Limin Su, Ming Liu, Yi Sun, Baoxue Yang, Hong Zhou
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Subjects:	Autosomal dominant polycystic kidney disease (ADPKD) Chronic kidney disease (CKD) cAMP-PKA signaling pathway Transforming growth factor-β1 (TGF-β1) Extracellular regulated protein kinase (ERK)
Online Access:	http://www.karger.com/Article/FullText/430160