Regulating macrophage-MSC interaction to optimize BMP-2-induced osteogenesis in the local microenvironment

Bone morphogenetic protein (BMP-2) has been approved by the FDA to promote bone regeneration, but uncertain osteogenic effect and dose-dependent side effects may occur. Osteoimmunomodulation plays an important role in growth factor-based osteogenesis. Here, we explored how proinflammatory signals af...

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Bibliographic Details

Published in:	Bioactive Materials
Main Authors:	Fei Jiang, Xuanyu Qi, Xiaolin Wu, Sihan Lin, Junfeng Shi, Wenjie Zhang, Xinquan Jiang
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2023-07-01
Subjects:	BMP-2 Osteogenesis IL-1β IL-1Ra Macrophage-MSC interaction
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X23000397