A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation

BackgroundChronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs). Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme of immune tolerance catalyzing the initial step of tryptophan degradation along the so-called l-kynurenine (l-kyn) pathway, that...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Massimo R. Mannarino, Vanessa Bianconi, Giulia Scalisi, Luca Franceschini, Giorgia Manni, Alessia Cucci, Francesco Bagaglia, Giulia Mencarelli, Francesco Giglioni, Doriana Ricciuti, Filippo Figorilli, Benedetta Pieroni, Elena Cosentini, Eleonora Padiglioni, Cecilia Colangelo, Dietmar Fuchs, Paolo Puccetti, Antonia Follenzi, Matteo Pirro, Marco Gargaro, Francesca Fallarino
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	EPC — endothelial progenitor cells kynurenine (KYN) IDO1 enzyme low-grade inflammation IL-6 (interleukin 6) hs-CRP (high sensitivity C-reactive protein)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.964660/full