Targeted Delivery of Amantadine-loaded Methacrylate Nanosphere-ligands for the Potential Treatment of Amyotrophic Lateral Sclerosis

Purpose. This study aimed to develop and analyse poly(DL-lactic acid)-methacrylic acid nanospheres bound to the chelating ligand diethylenetriaminepentaacetic acid (DTPA)  for the targeted delivery of amantadine in Amyotrophic Lateral Sclerosis (ALS). Methods. The nanospheres were prepared by a doub...

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Bibliographic Details

Published in:	Journal of Pharmacy & Pharmaceutical Sciences
Main Authors:	Zamanzima Mazibuko, Sunaina Indermun, Mershen Govender, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Girish Modi, Dinesh Naidoo, Viness Pillay
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Online Access:	https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/29595