AUF1-mediated inhibition of autophagic lysosomal degradation contributes to CagA stability and Helicobacter pylori-induced inflammation

CagA, a virulence factor of Helicobacter pylori (H. pylori), is known to drive inflammation in gastric epithelial cells and is typically degraded through autophagy. However, the molecular mechanism by which CagA evades autophagy-mediated degradation remains elusive. This study found that H. pylori i...

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Bibliographic Details

Published in:	Gut Microbes
Main Authors:	Huiling Zheng, Ting Zhang, Jing Zhang, Jing Ning, Weiwei Fu, Ye Wang, Yanyan Shi, Guochao Wei, Xiangmei Chen, Shigang Ding
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	CagA degradation AUF1 Helicobacter pylori-gastritis
Online Access:	https://www.tandfonline.com/doi/10.1080/19490976.2024.2382766