Automatic block-wise genotype-phenotype association detection based on hidden Markov model

Abstract Background For detecting genotype-phenotype association from case–control single nucleotide polymorphism (SNP) data, one class of methods relies on testing each genomic variant site individually. However, this approach ignores the tendency for associated variant sites to be spatially cluste...

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Bibliographic Details

Published in:	BMC Bioinformatics
Main Authors:	Jin Du, Chaojie Wang, Lijun Wang, Shanjun Mao, Bencong Zhu, Zheng Li, Xiaodan Fan
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Hidden Markov model Genome-Wide Association Study Block-wise Association EM algorithm
Online Access:	https://doi.org/10.1186/s12859-023-05265-5