DNA methylation and machine learning: challenges and perspective toward enhanced clinical diagnostics

Abstract DNA methylation is an epigenetic modification that regulates gene expression by adding methyl groups to DNA, affecting cellular function and disease development. Machine learning, a subset of artificial intelligence, analyzes large datasets to identify patterns and make predictions. Over th...

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Bibliographic Details

Published in:	Clinical Epigenetics
Main Authors:	Erfan Aref-Eshghi, Arash B. Abadi, Mohammad-Erfan Farhadieh, Amirreza Hooshmand, Fatemeh Ghasemi, Leila Youssefian, Hassan Vahidnezhad, Taylor Martin Kerrins, Xiaonan Zhao, Mahdi Akbarzadeh, Hakon Hakonarson, Amir Hossein Saeidian
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	DNA methylation Machine learning Epigenetics CpG sites Clinical application
Online Access:	https://doi.org/10.1186/s13148-025-01967-0