TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex

Summary: Individuals within the amyotrophic lateral sclerosis and frontotemporal dementia disease spectrum (ALS/FTD) often experience disruptive mental behaviors and sleep-wake disturbances. The hallmark of ALS/FTD is the pathological involvement of TAR DNA-binding protein 43 (TDP-43). Understanding...

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Bibliographic Details

Published in:	iScience
Main Authors:	Hongxia Zhang, Chen Chen, Eric Erquan Zhang, Xiaotian Huang
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Subjects:	Molecular biology Neuroscience Molecular neuroscience Cellular neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224007430